Dra. Margareth Castro Ozelo

Brazilian citizen, was born on April 28th, 1970

Education University - Graduation in Medicine

- School of Medicine of the State University of Campinas (UNICAMP) Campinas – SP, Brazil
Period: since 1988 until 1993

Medical Residence

- Specialization in Haematology and Transfusion Medicine

School of Medicine of the State University of Campinas (UNICAMP)
Campinas – SP, Brazil
Period: since 1993 until 1996

Postgraduate

– Ph.D. degree - Physician, Department of Clinical Medicine, School of Medicine of the State University of Campinas (UNICAMP)
Campinas – SP, Brazil
Period: since 1998 until 2004


Postdoctoral Fellow

- Department of Pathology and Molecular Medicine - Richardson Laboratory, Queen's University, Kingston, ON, Canada.
Period: since August 2006 - present

Current position

- Disorders of Haemostasis, clinical assistant, outpatient clinic and clinical laboratory
Haematology and Transfusion Medicine Center of the State University of Campinas (UNICAMP) Campinas, SP – Brazil

- Responsible for the Haemostasis’ Laboratory of the Hematology and Transfusion Medicine Center of the UNICAMP

- Membership of the Haemophilia Committee of the State of São Paulo – Brazil

- Membership of the Scientific Committee from Brazilian Federation of Haemophilia

- Membership of the Latin American Group of Hemophilia and Inhibitors

Awards

- Young Investigator Award, XVIII Congress of the International Society on Thrombosis and Haemostasis, Paris- France, 2001.

- Early Career Investigator Award, the Bayer Hemophilia Awards Program For two-year grants: June 2003- June 2005.

- 4th ZLB Behring’s Grant for Haemophilia: simple things, great results. “Pedagogical support for patients with haemophilia”. August 2005.

- Reach the World Award application for the XXIst Congress of the International Society on Thrombosis and Haemostasis, Geneve-Switzerland, 2007.

Memberships in Professional and Scientific Societies:

- Brazilian College of Hematology (1996-present)
- Brazilian Federation of Hemophilia (1996-present)
- World Federation of Hemophilia (1998-present)
- American Society of Gene Therapy (2004-present)
- The American Society of Hematology (2005-present)
- International Society on Thrombosis and Haemostasis (2006-present)

Editorial Positions:

Reviewer for:
- 2004 - present "Thrombosis and Haemostasis"

Publications:

Schetert IT, Cardinalli IA, Ozello MC, Vassallo J, Lorand-Metze I, de Souza CA. Hemophagocytic syndrome: pitfalls in its diagnosis. Sao Paulo Med J. 1997 Sep-Oct;115(5):1548-52.

Arruda VR, Belangero WD, Ozelo MC, Oliveira GB, Pagnano RG, Volpon JB, Annichino-Bizzacchi JM. Inherited risk factors for thrombophilia among children with Legg-Calvé-Perthes disease. Journal of Pediatric Orthopaedics, 19: 84-87, 1999.

Eliana Nogueira, Valder R Arruda, Joyce M Annicchino Bizzacchi, Fernando F Costa, Margareth Castro Ozelo, Cláudio Lúcio Rossi, Sandra CB Costa. Possible association between Cytomegalovirus infection and gastrointestinal bleeding in hemophiliac patients. Acta Haematol 2000 May; 103: 73-77.

Singh YS, Arruda VR, Ozello MC, Machado TF, Annichino-Bizzacchi MM. Identification of one novel and three other point mutations in the protein C gene of five unrelated brazilian patients with hereditary protein C deficiency. Haematologica. 2000 Aug;85(8):891-3.

Torresan M, Machado TF, Siqueira LH, Ozelo MC, Arruda VR, Annichino-Bizzacchi JM. The impact of the search for thrombophilia risk factors among antiphospholipid syndrome patients with thrombosis. Blood Coagul Fibrinolysis. 2000 Oct;11(7):679-82.

Emmerich J, Rosendaal FR, Cattaneo M, Margaglione M, De Stefano V, Cumming T, Arruda V (including Ozello MC and Annichino-Bizzacchi JM), Hillarp A, Reny JL. Combined effect of factor V Leiden and prothrombin 20210A on the risk of venous thromboembolism - pooled analysiis of 8 case-control studies including 2310 cases and 3204 controls. Thromb Haemost 86:809-816, 2001.

AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B. Catherine S. Manno, Amy J. Chew, Sylvia Hutchison, Peter J. Larson, Roland W. Herzog, Valder R. Arruda, Shing Jen Tai, Margaret V. Ragni, Arthur Thompson, Margareth Ozelo, Linda B. Couto, Debra G. B. Leonard, Frederick A. Johnson, Alan McClelland, Ciaran Scallan, Erik Skarsgard, Alan W. Flake, Mark A. Kay, Katherine A. High, and Bertil Glader Blood 2003;101 2963-2972

Evaldo P Landi, Eduardo G Roveri, Margareth C Ozelo, Joyce M Annichino-Bizzacchi, Andreia F Origa, Aparecida RC Reis, Carmino A de Souza, José Francisco C Marques Jr. Effects of high platelet concentration in collecting and freezing dry platelets concentrates. Transfus Apheresis Sci. 2004 Jun;30(3):205-12.

Margareth C. Ozelo, Andrea F. Origa, Francisco J. P. Aranha, Antonio P. Mansur, Joyce M Annichino-Bizzacchi, Fernando F. Costa, Eleanor S. Pollak, Valder R. Arruda. Platelet glycoprotein Iba polymorphisms modulate the risk for myocardial infarction. Thromb Haemost. 2004 Aug;92(2):384-6.

Margareth C. Ozelo, Devanira S. P. Costa, Lucia H. Siqueira, Vagner Castro, Marilda S. Gonçalves, Raimundo C. Menezes, Manoel Soares, Joyce M. Annichino-Bizzacchi, Fernando F. Costa, Valder R. Arruda. Genetic Variability of Platelet Glycoprotein Iba Gene Am J Hematol. 2004 Oct;77(2):107.

MW Skinner, DP Lillicrap, J McMillian, MC Ozelo, GF Pierce. Genetic aspects of Haemophilia: What is a cure and how do we get there? Haemophilia (2004), 10, (S4), 115-118.

Goedert JJ, The Seceond Multicenter Hemophilia Cohort Study (including Margareth Ozelo). Prevalence of conditions associated with human immunodeficiency and hepatitis virus infections among persons with haemophilia, 2001-2003. Haemophilia. 2005 Sep;11(5):516-28.

Margareth C. Ozelo, Pavel Svirin, Lubov Larina. Use of recombinant factor VIIa (rFVIIa) in the management of severe bleeding episodes in patients with Bernard-Soulier syndrome. Annals of Hematology (2005) Dec;84(12):816-22.

Mingdong Zhang, Philip S. Rosenberg, Deborah L. Brown, Liliana Preiss, Barbara A. Konkle, M. Elaine Eyster, and James J. Goedert, for the Second Multicenter Hemophilia Cohort Study (including Margareth Ozelo). Correlates of spontaneous clearance of hepatitis C virus among people with hemophilia. Blood (2006) 107 892-897.

MEP Corrêa, JM Annichino-Bizzacchi, J Jorge, OP Almeida, MC Ozelo, FJP Aranha, ML Barjas-Castro. Clinical impact of oral health indexes in dental extraction of hemophilic patients. J Oral Maxillofac Surg. 2006 May;64(5):785-8.

Catherine S. Manno, Glenn F. Pierce, Bertil Glader, Valder R. Arruda, Margaret Ragni, John Rasko, Margareth C. Ozelo, Keith Hoots, Philip Blatt, Barbara Konkle, Michael Dake, Robin Kaye, Mahmood Razavi, Albert Zajko, James Zehnder, Hiroyuki Nakai, Amy Chew, Debra Leonard, J. Fraser Wright, Jürg Sommer, Michael Tigges, Denise Sabatino, Alvin Luk, Haiyan Jiang, Federico Mingozzi, Linda Couto, Hildegund C. Ertl, Katherine A. High, Mark A. Kay. AAV-mediated, liver-directed gene transfer for severe hemophilia B: successful transduction and limitations imposed by the host immune response. Nat Med. 2006 Mar;12(3):342-7. Epub 2006 Feb 12.

Erich V. De Paula, Joyce M. Annichino-Bizzacchi, Mariane C. F. Nascimento, Celso D. Ramos, Margareth C. Ozelo, Tânia F. G. S. Machado, Ana T. Guillaumon, Valder R. Arruda. Early in vivo anticoagulation inhibits the angiogenic response following hindlimb ischemia in a rodent model. Thromb Haemost. (2006) Jul;96(1):68-72.

Luciana M Hollanda, Carmen S P Lima, Anderson F Cunha, Dulcinéia M Albuquerque, José Vassallo, Margareth C Ozelo, Paulo P Joazeiro, Sara T O Saad, Fernando F Costa. An inherited mutation leading to production of only the short isoform of GATA-1 is associated with impaired erythropoiesis. Nat Genet. (2006) Jul;38(7):807-12. Epub 2006 Jun 18.

Haiyan Jiang, Glenn F. Pierce, Margareth C. Ozelo, Erich V de Paula, Alvin Luk, Joseph A. Vargas, Catherine S. Manno, Katherine A. High, Valder R. Arruda. Evidence of multi-year factor IX expression by AAV-mediated gene transfer to skeletal muscle in an individual with severe hemophilia B. Mol Ther. 2006 Sep;14(3):452-5. Epub 2006 Jul 5.Alessio AM, Hoehr NF, Siqueira LH, Ozelo MC, de Paula Mansur A, Annichino-Bizzacchi JM. Association between estrogen receptor alpha and beta gene polymorphisms and deep vein thrombosis. Thromb Res. Epub 2006 Dec 19.

Scientific Exhibits

Presented 68 Scientific Exhibits in Congresses in Brazil, Europe, Asia and North America.

Teaching Experience

Invited lecturer in 39 regional congresses and courses (Brazil).
Invited lecturer in 3 international congresses. 

April, 2007.
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